Company description
Creative Peptides has developed an innovative peptoid synthesis service to meet the increasing needs in drug target discovery and lead structure discovery research, providing a confidential and efficient service at competitive prices.
Below is a list of our available peptoid side chain (include but not limited to the following):
Solid-Phase Synthesis
The first oligopeptoids reported were synthesized by solid-phase synthesis, for which a set of Fmoc-protected peptoid monomers was made. There are several advantages to this method, but the extensive synthetic effort required to prepare a suitable set of chemically diverse monomers is a significant disadvantage of this approach. Additionally, the secondary N-terminal amine in peptoid oligomers is more sterically hindered than the primary amine of an amino acid, which slows coupling reactions.
• Sub-monomer Solid-Phase Method
A major breakthrough came in 1992 when a much more efficient method of peptoid synthesis was invented. In this method, each N-substituted glycine (NSG) monomer is assembled from two readily available “sub-monomers” in the course of extending the NSG oligomer, this method is known as the sub-monomer method, in which each cycle of monomer addition consists of two steps, an acylation step and a nucleophilic displacement step.
