45 Ramsey Road
Shirley 11967
United States
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Company description

Creative Peptides has launched a series of MHC-peptide Tetramers which are ready-to-use reagents conjugated to a fluorochrome group such as Brilliant Violet 421(BV421), phycoerythrin (PE), or allophycocyanin (APC).

In 1996, the development of reagents consisting of soluble MHC class Iā€“peptide complexes, which was applied to detect CD8+ cells by flow cytometry, had effectively promoted a revolution of antigen-specific T cells. Traditionally, TCR (T cell receptor) has a low avidity and fast off-rate for MHC-peptides complexes, recombinant soluble monomeric MHC-peptide complexes have not been used to detect antigen-specific T cells. Recently, Stanford University School of Medicine has presented MHC-peptides tetrameric complexes (MHC tetramers) in the detection of antigen-specific T cells, thus provided an efficient method to visualize, quantify, phenotype and sort antigen-specific cytotoxic T lymphocytes (CTLs) directly from a wide range of biological samples and have now become standard reagents in laboratories around the world.


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