Founded in 1786, Knoxville is the third-largest city in the U.S. state of Tennessee, U.S.A., behind Memphis and Nashville, and is the county seat of Knox County. It is the largest city in East Tennessee, and the second-largest city (behind Pittsburgh) in the Appalachia region. Of Tennessee's four major cities, Knoxville is second oldest to Nashville, which was founded seven years earlier. After Tennessee's admission into the Union in 1796, Knoxville was the state's first capital, in which capacity it served until 1819, when the capital was moved to Murfreesboro, prior to Nashville receiving the designation. The city was named in honor of the first Secretary of War, Henry Knox.