Huntsville is a city located primarily in Madison County in the central part of the far northern region of the U.S. state of Alabama. Huntsville is the county seat of Madison County. The city extends west into neighboring Limestone County. John Hunt first settled in the location in 1805. It was named Twickenham after Alexander Pope's English home at the request of LeRoy Pope. However, the town was renamed "Huntsville" on November 25, 1811 after its first settler.